St. John’s Wort is also known as Tipton’s Weed, Chase-devil, or Klamath weed.
St. John’s Wort has become popular again as an antidepressant. It is the number one treatment in Germany and has been extensively studied by Commission E, the scientific advisory panel to the German government. It contains several chemicals, including hypericin, hyperforin, and pseudohypericin, which are thought to be the major sources of antidepressant activity. In several studies of laboratory animals and humans, one or more of the chemicals in St. John’s wort appeared to delay or decrease re-absorption of the neurotransmitters dopamine, norepinephrine, and serotonin by nerve cells.
Neurotransmitters are chemicals that carry messages from nerve cells to other cells. Ordinarily, once the message has been delivered, neurotransmitters are re-absorbed and inactivated by the cells that released them. Chemicals in St. John’s wort may keep more of these antidepressant neurotransmitters available for the body to utilise. Multiple studies have shown that St. John’s wort may be effective in relieving mild to moderate depression, although maximum antidepressant effects may take several weeks to develop.